A recent study suggests that people who come off popular slimming jabs like semaglutide or tirzepatide may regain lost weight much more quickly than those who halt conventional diet and exercise regimens.
Findings released in a major medical journal demonstrates that while overweight individuals can lose about a fifth of their total mass while undergoing treatment, the weight returns at an estimated rate of 0.8 kg per month once they quit.
"People using these treatments need to be cognizant of the risk of fast rebound weight gain when the medication is stopped," cautioned lead investigator Dr. Susan Jebb.
This pace of regain means a return to original weight in about a year and a half.
Analyzing Therapies
The study, which looked at 37 of studies involving thousands of participants, contrasted the outcomes of the injectable medications with older methods.
The team note that people who lose weight through lifestyle changes alone usually see a slower weight regain—perhaps 0.1 kg a month—after stopping.
Understanding the Quick Regain
Experts suggest the way of the injections accounts for the accelerated rebound.
The injections imitate a natural hormone called GLP-1, which helps regulate hunger.
"Long-term administration of GLP-1 concentrations several times higher than the body's typical production may cause the body to produce less of its own natural GLP-1, and may also diminish responsiveness to its effects," explained Dr. Adam Collins, a dietetics specialist.
"Discontinuation of this GLP-1 'fix' results in appetite is no longer kept in check, making binge eating far more likely."
A Chronic Condition?
The NHS recommend the jabs for people with weight-linked medical conditions, accompanied by recommended diet and exercise modifications.
Many experts say that, given the likelihood of relapse, the therapy should be considered long-term.
This view is reinforced by drug manufacturers, who state that the findings "highlight the long-term character of obesity," comparing it to managing diseases like hypertension.
Patient Testimonies
Users who have discontinued the medication describe a powerful return of hunger.
"I experienced something that goes on and you're instantly extremely hungry," described an individual.
This difficulty is exacerbated if users have not developed permanent dietary or behavioural modifications during treatment.
Significant Interest
Recent estimates show that millions of adults in the UK have used weight-loss jabs in the last 12 months, with interest remaining high.
- Adoption is higher among females than males.
- The 40s and 50s age group shows the greatest usage rates.
- A large proportion obtain the drugs through private prescriptions rather than the NHS.
Finally, experts stress that while the jabs are potent tools for weight loss, they are not a permanent cure and maintained weight loss relies on integrated lifestyle management.
